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This raises an important point. What would the primary skill be? It's not very clear from the sample character which are the "main" skills and which are purely complementary.

I would say that the active skills would be the "main" skills, if only because they allow you to make concrete actions in game.

I meant in a general sense. From my personal view (biased as it may be) characters "do" things and doing things is active. The pass/fail yes/no moment when a character does something is when they take the knowledge and put it into practice. Sure you can do an opposed test Academics: Biology when debating with a colleague but in this case you are actually creating life. And theorizing about making life and actually going around making life are two things (one of these two things requires a budget :D). So in this specific case if we use the Brinker Genehack as someone with the skills necessary to alter a biomorph the active skills would be his medicine skills backed up by his knowledge skills. I'd make him roll two modified skills them being: Medicine (gene therapy) to play with the genes in the first place and then a shot of Medicine (nanomedicine) to alter them further to do things that the genes were not supposed to do, that's the hacking part. Note that this guy is not equipped to make life from scratch, he alters one form of life into another. He has to start with something alive in the first place because he is woefully inadequate at chemistry. So this guy is gonna need something like stem cells or something else alive to change. I don't see him making a biomorph because he has the wrong skills, however I can see him modify an existing biomorph but it will be a derivative work.