I noted that Charles Stross had a nice thread on existential risks: http://www.antipope.org/charlie/blog-static/2011/06/existential-threats.... Any more we can add to the list in this thread? http://www.eclipsephase.com/extinction-scenarios He also has a fine analysis of why nukes have become less favoured: http://www.antipope.org/charlie/blog-static/2011/06/obsolete-existential... While I think the threat has not gone away much, it is good input for any GM who wants to consider the superweapons of the EPverse. (also, for some fun ideas for back-to-the-really-old-roots transhumanism: http://www.antipope.org/charlie/blog-static/2011/07/federovs-rapture.html - I have always liked that one of the minor characters in the game Alpha Centauri is named after him).