To go with the topics about music and art: a more interactive medium. Deus Ex - obviously. In addition, Deus Ex: Human Revolution is explicitly about transhumanism and has the H+ logo in its trailers. Iron Seed - this ancient MS-DOS game turned me on to the idea of transhumanism before I even knew what that word was. The plot of the game is that some great calamity happened on Earth, leading to an exodus to Mars. Many years later, a brutal crackdown drove out many religious individuals. Six of them were uploaded into a (slightly-customizable) ship named the Iron Seed and set off to find new worlds to colonize. One of the six positions, responsible for keeping the crew sane, is named "Psychometrist" instead of psychosurgeon. They meet aliens who feel truly alien and incomprehensible, although the final part of the game is a basic save-the-galaxy quest. One wonders if perhaps the developers of this game and the founders of Posthuman Studios once travelled in the same circles back in the early 90's... Metal Gear - despite starting out as a tactical espionage action game with occasional science-fiction elements, it eventually started tackling nanotechnology, memetic attacks, methods by which AIs can control the whole world, etc. DoDonPachi DaiOuJou - the three protagonists, referred to as Element Dolls, are AIs who were originally designed to serve humankind, assist the elderly, and interface with complex information systems. When a robotic threat roars its head, the Element Dolls are forced into prototype fighter planes and sent to fight the enemy. In the end, one of them falls in love with a human operator, while another one of them is affected by the enemy program and goes berserk. The gameplay itself is not very related to H+ or horror, but it is pretty fun. Syndicate - this was an old tactical/strategy game about corporations who fight for world domination via violent operations carried out by drug-filled cyborgs. The population at large is kept sedated thanks to implanted chips and drug delivery systems, and they can be mind-controlled to form a sort of tactical network that will eventually overwhelm the anti-hacking defenses of enemy cyborgs. Opera Omnia - this is a small independent game that can be found at http://www.increpare.com/2009/02/opera-omnia/ for free. Although the game is mostly about rewriting history in order to suit political goals, it also shows a lot of different possibilities for memetic attacks and culture-hacking for the purpose of warfare.