Informorphs think the same way normal people do, and have more or less the same interaction with the world. In a simulmorph world (where they have a virtual body), their experience is probably pretty indistinguishable from yours in reality. They don't have a physical body, so their input comes from the various sensors in the world (sometimes from robots that they are piloting). They also may be interacting with virtual input. When you're reading something on your monitor, you're seeing the data turned into physical light, and then you're processing that back into data. For them, this can be a direct path, where they just "see" the data. This is probably an option for any character in the world with mesh inserts, though. Similarly, when they want to change things in the physical world, they generally will do so through robotic proxies. Without the input and output through these data channels, it's probably like being paralyzed in a hospital, and simultaneously losing your sight, hearing, and other senses. Fortunately, with a steady stream of digital interaction available, there's no reason for them to be find that distressing. Of course, there are some people (e.g. Jovians) that feel that infomorphs are not real people, or that they no longer have souls, but these are concepts that have no real basis (they may be true, but there's no way to determine whether they are).