Have you thought anytime about to change radically the canon background to mix your favorite franchises?
For example a galaxy with all alien races from Star Wars, Star Treck, Andromeda, Farscape, Stargate SG-1, Doctor Who, Babylon 5, Earth: Final Conflict, the invaders, V, Falling Skies, Firefly, First Wave, UFO, Colony, Defiance, Starship Troopers, Mass Effect, Halo, Destiny, Dead Space, System Shock, Deux Ex, D&D Spelljammer, d20 Future(Star*Drive + Star Frontiers + Gamma World + Dark*Matters), Fading Suns, Warhammer 40.000, Shadowrun, Starcraft, Flash Gordon, Buck Rogers, DC and marvel comics universes...
What about mixing backgrounds from "Eclipse Phase" and "Chulhutech"?
Other idea is adding supernatural elements to cause surprise and playing with ambiguty. Are those strange beings from the lost spaceship incorporeal alien creatures, or really ghosts of the original crew? Is that man really fool or a true cursed werewolf-like creature?
Or adding the "supernatural factions" from "Kult: lost divinity". It would be like a mixture of Doom videogame, Event Horizon(movie), Hellraiser: Bloodline(Pinhead in the space), Clave Baker's Jericho (videogame), Dead Space, System Shock videogames, Bioshock, X-Files and Lovecraft's myths. (But adding step by step, insinuating more than showing).
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The Master Confucius said: “The noble man is in harmony but does not follow the crowd. The inferior man follows the crowd, but is not in harmony.” (Anaclet 13:23).