Yes combat skills can be complimented by knowledge skills. The Wrecker profession in Transhuman is a pretty good example. Profession: Small unit Tactics can compliment initiative Interest: Spaceship Models can compliment Gunnery Profession: Security Admin can compliment infosec intrusions Academics: Anatomy could compliment a blade weapons attack On the other hand there are unlimited situations where these skills are not so much complimentary but necessary for a character to accomplish a task. For instance a character probably needs some knowledge of exotic morphology and anatomy to effectively battle some of the weird new morphs in gatecrashing or transhuman that they've never seen before. If it seems to unbalance your game or players try to abuse the complimentary skill mechanic you can try any of several alternate rules. 1. Instead of complimentary skills adding a automatic bonus, demand a complimentary skill check and use the MOS/MOF as a modifier to the activity roll. This one works well for me because: A; it gives players a reason to actively roll dice on a knowlege skill which doesn't happen often otherwise. B; it keeps PC's from relying on a modicum of familiarity for an automatic +10 bonus. C; it empowers non combat characters during stressful situations. 2. Complimentary skills only come into effect when there is a negative modifier that the knowledge might mitigate. For me this rule does a good job of simulating that Intrest:exotic morphology really does help the first time your character has to fist fight an octopus when they would have a negative modifier for being unfamiliar but doesn't really help a character line up that headshot on a ruster. I also reccomend these rules when your players realize that they can use their muse for teamwork bonuses on virtually everything.