So I've been considering the questions raised by Fermi's Paradox, but looking at it from a different perspective than I usually do. Instead of trying to determine if there's life out there and if so where is it, I've been examining what must be true about life should it be out there. And while a lot of us hard sf fans like to point out how truly alien creatures that evolved on another planet should be, there are a few things we can surmise.
For one, the Aliens would have evolved to sentience through evolutionary forces roughly analogous to the ones on earth. Natural Selection and Competition. In particular they would have a tendency to want to avoid death, at least until they reproduced. It would seem likely they would be familiar with Cooperation as concept as well as Competition since evolution on earth seems to use both techniques rather extensively, regardless of how natural the concept is for them. And as they developed technology it seems almost certain that they would be aware of rapidly accelerating growth in terms of technology, and how much powerful one species can be from another with as little as 1000 years of advancement.
So let's assume these...First-ians evolved somewhere in our galaxy and rise to a state of scientific and technological mastery. They would also face the question of "Our we alone in the universe?" and even though they're the first they have no way of knowing that. Further, they realize that another species, even as little as a million years more advanced then they, would hopelessly outclass them, and since they have an effective fear of death, a logical evolutionary strategy would be to hide. If they choose to hide, then the next species that evolves in the galaxy would effectively be First-ians as well and could reasonably follow the same pattern.
To summarize: All advanced civilizations eventually decide to hide from hypothetical hyper advanced aliens which they fear could do them harm.
In particular, a sufficiently advanced being and/or civilization might even be able to impersonate less advanced cultures in an attempt to lure victims civilizations out into the open. For that matter, it could even create them. Given the potential threat from these - albeit hypothetical - aggressive aliens, I see no logical reason why any alien race would be willing to risk communicating with another, even one that seems less advanced.
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The end really is coming. What comes after that is anyone's guess.