There are many variations to the typical medieval European setup in fantasy. D&D's Eberron has many more modern technologies such as trains and heating devices, just mass produced through magic. Very little in the way of serfs and lords except in pre-war cultures their. Or you could have fantasy that's otherwise set in the modern world, but with the inclusion of magic. Think Shadowrun, but without the hi-tech. Or D&D's Starjammer. Which acts like a space opera but with galleons sailing the stars rather than traditional space vehicles. "Fantasy" may conjure up an image of dwarves and elves, but it can mean any impossible, wondrous scenario. Hell, a setting that employs transhumanism, as feasible as it might be, could be considered a "fantasy."

EP's rules are fine for people who like percentile systems. I'd argue that you could definitely work the ego/morph split into other systems (like FATE derivatives or Savage Worlds) instead of dropping another setting onto EP. One of the considerations is that EP's combat revolves around the use of guns, which most fantasy games seldom deal with dispite the mediaeval period containing gonnes, cannons and handgonnes. Bringing up Eberron makes an intersting idea. Since the warforged are cyborgs with stolen/fabricated spirits, could one not make similar shells and transfer consciousness to them? D&D, though not a fan, has some great construct artwork from the prolific 3rd and 3.5 edition monster manuals throughout it that could lend to the different shell varieties. Though, I would hate to run such a game on anything but the inside of a dyson sphere (or hourglass ala Last Exile).

Transhumanism and fantasy can be combined, but the result is very non-classical. Fantasy tends to be rooted in a somewhat particular worldview where the world is static (a "natural order"). When you start approaching the fantasy world with a transhumanist mindset you start questioning the human condition (and the elf, orc and dragon ones). You start taking advantages of the physics and magic in ways that normally would be munchkin but here applicable outside the gamer party. After all, if there is a resurrection spell, why does any king ever die? A simple elemental summoning can revolutionize industry. A perpetual motion spell (or even one that needs to be replenished every morning) and you have a magical steam engine. The end result can be interesting: we ran a campaign where characters were enhanced using magical tattoos and setting up assembly line manufacturing (consider the effect of a never sleeping, speeded up, Leonardo-level engineer), the big empire got wiped out because of innovative use of resources (elves with night vision + flying + bombs = destroyed army camps before they could reach their enemies) and undead were turned into computers (running Fortran, of all languages). It wrecked the traditional fantasy world order, producing something like a welfare state Mordor run by transhumans. In the above case the setting was exploring the collision between the different approaches. One can of course construct a setting where the approaches are more integrated. But I think it is tough to do without either forcing a stabilizing natural order, or having a dynamical setting where the natural order is being changed.

People are talking about transhumanist fantasy.... nWoD gets mentioned as a system... How is it I am the first to mention Exalted?