It seems like a natural enough fit; the Exsurgent Virus would probably be a trap laid by the ETI/Transcendants to catch those species who don't follow the path encouraged by the Galactic Libraries; if you tried to look up the Pandora Gates in the Galactic Libraries, you'd just get a "memetic hazard" warning and little more. The Factors were likely a species that went off the tracks a bit, and only barely survived their Singularity event; they noticed when Transhumanity did the same, and decided to adopt a wait-and-see approach to see how a wolfling species dealt with it. Then the Tymbrimi notice something odd about the Factors' behavior, and follow one of their ships to discover transhumanity. Hilarity ensues as transhumanity makes contact with the Five Galaxies. Possibly literally when the Tymbrimi get mistaken for pranksterish transhumans. On the one hand, they've uplifted a half-dozen species from the homeworld, created a few brand new forms of the Mechanical order of life, are busily terraforming a bunch of planets, and are in the process of uplifting at least one alien species (and have discovered at least three or four upliftable species). On the other, the TITANs wrecked the Earth, and left to do god-knows-what in the greater galaxy, and that would likely earn transhumanity some condemnation. And, of course, the Player Characters, as agents of Firewall, would be right in the middle of the resulting political firestorm as the aliens try to figure out what the heck to do with transhumanity. It could make a decent political game, as they try to convince the Galactics that transhumanity can stand on their own two feet without needing to be indentured to a patron species. And cause headaches for their bureaucrats when they try to figure out how to classify things like pods and suryas.